In this film Doolittle (Robert Downey, Jr.) has lost his wife and become a man confined to his home and just attending to his animals, all who talk with him, he no longer wants contact with human beings.
The plot begins when the Queen Victoria sends a message, ordering Doolittle to come to her and help cure her of a deadly sickness. Doolittle finds the Queen has eaten a poisonous substance. The only cure is for her to eat a fruit from a far away land. Doolittle along with Tommy Stubbins (Harry Collett) who has persuaded Doolittle to save a squirrel Tommy has accidentally shot and the team of animals head off to save the Queen.
They are met and captured by Rassouli (Antonio Banderas) in a silly part. Michael Sheen is also in a less than quality part as part of the conspiring folks who want the Queen to die and therefore must stop Doolittle from bring the toxin which can save the Queen back to England.
There are battles on the sea and the animals all pitch in to help Doolittle save the good Queen Victoria. The most effective scenes are around the fire spraying dragon which Doolittle can talk down.
As we would expect it all turns out well and both the Queen and the animals are happy again with Doolittle, but those of us watching are having difficulty staying awake in this silly presentation.